Molecular Biology of the Gene pdf mobi txt 2024 电子版 下载

The classic textbook in molecular biology, updated with new chapters, new information, and new media.

Completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson’s classic text, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

Two new chapters discuss the emerging research fields of Regulatory RNAs (Chapter 18) and Genomics and Systems Biology (Chapter 20), and give particular focus on RNAi, microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks.

Every chapter includes thorough content updates, and where relevant, the inclusion of medical insights that have emerged from our understanding of basic molecular biology, and references that direct students to explore the expanded companion website.

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James D. Watson was Director of Cold Spring Harbor Laboratory from 1968 to 1993, President from 1994 to 2003, and is now its Chancellor. He spent his undergraduate years at the University of Chicago and received his Ph.D. in 1950 from Indiana University. Between 1950 and 1953, he did postdoctoral research in Copenhagen and Cambridge, England. While at Cambridge, he began the collaboration that resulted in the elucidation of the double-helical structure of DNA in 1953. (For this discovery, Watson, Francis Crick, and Maurice Wilkins were awarded the Nobel Prize in 1962.) Later in 1953, he went to the California Institute of Technology. He moved to Harvard in 1955, where he taught and did research on RNA synthesis and protein synthesis until 1976. He was the first Director of the National Center for Genome Research of the National Institutes of Health from 1989 to 1992. Dr. Watson was sole author of the first, second, and third editions of Molecular Biology of the Gene, and a co-author of the fourth and fifth editions. These were published in 1965, 1970, 1976, 1987, and 2003, respectively. He is also a co-author of two other textbooks: Molecular Biology of the Cell and Recombinant DNA.

Tania A. Baker is the Whitehead Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. She received a B.S. in biochemistry from the University of Wisconsin, Madison, and a Ph.D. in biochemistry from Stanford University in 1988. Her graduate research was carried out in the laboratory of Professor Arthur Kornberg and focused on mechanisms of initiation of DNA replication. She did postdoctoral research in the laboratory of Dr. Kiyoshi Mizuuchi at the National Institutes of Health, studying the mechanism and regulation of DNA transposition. Her current research explores mechanisms and regulation of genetic recombination, enzyme-catalyzed protein unfolding, and ATP-dependent protein degradation. Professor Baker received the 2001 Eli Lilly Research Award from the American Society of Microbiology and the 2000 MIT School of Science Teaching Prize for Undergraduate Education and was elected as a fellow of the American Academy of Arts and Sciences in 2004. She is co-author (with Arthur Kornberg) of the book DNA Replication, Second Edition.

Stephen P. Bell is a Professor of Biology at the Massachusetts Institute of Technology and an Investigator of the Howard Hughes Medical Institute. He received B.A. degrees from the Department of Biochemistry, Molecular Biology, and Cell Biology and the Integrated Sciences Program at Northwestern University and a Ph.D. in biochemistry at the University of California, Berkeley in 1991. His graduate research was carried out in the laboratory of Dr. Robert Tjian and focused on eukaryotic transcription. He did postdoctoral research in the laboratory of Dr. Bruce Stillman at Cold Spring Harbor Laboratory, working on the initiation of eukaryotic DNA replication. His current research focuses on the mechanisms controlling the duplication of eukaryotic chromosomes. Professor Bell received the 2001 ASBMB–Schering Plough Scientific Achievement Award, the 1998 Everett Moore Baker Memorial Award for Excellence in Undergraduate Teaching at MIT and the 2006 MIT School of Science Teaching Award.

Alexander A. F. Gann is Editorial Director of Cold Spring Harbor Laboratory Press, and a faculty member of the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. He received his B.Sc in microbiology from University College London and a Ph.D. in molecular biology from The University of Edinburgh in 1989. His graduate research was carried out in the laboratory of Noreen Murray and focused on DNA recognition by restriction enzymes. He did postdoctoral research in the laboratory of Mark Ptashne at Harvard, working on transcriptional regulation, and that of Jeremy Brockes at the Ludwig Institute of Cancer Research at University College London, where he worked on newt limb regeneration. He was a Lecturer at Lancaster University, U.K., from 1996 to 1999, before moving to Cold Spring Harbor Laboratory. He is co-author (with Mark Ptashne) of the book Genes & Signals (2002).

Michael Levine is a Professor of Molecular and Cell Biology at the University of California, Berkeley, and is also Co-Director of the Center for Integrative Genomics. He received his B.A. from the Department of Genetics at University of California, Berkeley, and his Ph.D. with Alan Garen in the Department of Molecular Biophysics and Biochemistry from Yale University in 1981. As a postdoctoral fellow with Walter Gehring and Gerry Rubin from 1982-1984, he studied the molecular genetics of Drosophila development. Professor Levine's research group currently studies the gene networks responsible for the gastrulation of the Drosophila and Ciona (sea squirt) embryos. He holds the F. Williams Chair in Genetics and Development at University of California, Berkeley. He was awarded the Monsanto Prize in Molecular Biology from the National Academy of Sciences in 1996, and was elected to the American Academy of Arts and Sciences in 1996 and the National Academy of Sciences in 1998.

Richard M. Losick is the Maria Moors Cabot Professor of Biology, a Harvard College Professor, and a Howard Hughes Medical Institute Professor in the Faculty of Arts & Sciences at Harvard University. He received his A.B. in chemistry at Princeton University and his Ph.D. in biochemistry at the Massachusetts Institute of Technology. Upon completion of his graduate work, Professor Losick was named a Junior Fellow of the Harvard Society of Fellows when he began his studies on RNA polymerase and the regulation of gene transcription in bacteria. Professor Losick is a past Chairman of the Departments of Cellular and Developmental Biology and Molecular and Cellular Biology at Harvard University. He received the Camille and Henry Dreyfuss Teacher-Scholar Award, is a member of the National Academy of Sciences, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Association for the Advancement of Science, a Fellow of the American Academy of Microbiology, a member of the American Philosophical Society, and a former Visiting Scholar of the Phi Beta Kappa Society. Professor Losick is the 2007 winner of the Selman A. Waksman Award of the National Academy of Sciences.

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在线阅读地址：Molecular Biology of the Gene在线阅读

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Life is difficult to define because it is a process, not a thing.

书籍介绍

The classic textbook in molecular biology, updated with new chapters, new information, and new media.

Completely up-to-date with the latest research advances, the Sixth Edition of James D. Watson’s classic text, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly respected biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

Two new chapters discuss the emerging research fields of Regulatory RNAs (Chapter 18) and Genomics and Systems Biology (Chapter 20), and give particular focus on RNAi, microRNAs, the opportunities offered by the new generation of genome technologies, and the elucidation of gene regulatory networks.

Every chapter includes thorough content updates, and where relevant, the inclusion of medical insights that have emerged from our understanding of basic molecular biology, and references that direct students to explore the expanded companion website.

• 作者：岛 发布时间：2013-11-03 04:30:16

  凡是课程涉及的都看了，编的很好各种mechanism讲的都很透彻，就是看了记不住啊。。。。

• 作者：混入 发布时间：2020-07-23 15:59:45

  从头到尾，充满男性凝视，每读10分钟都要停下来生一会儿气。我实在无法喜欢。

• 作者：咩店头牌小王子 发布时间：2013-11-03 04:55:29

  我突然想起来我还真心看过................................不过还是很想重新看一遍分子的的玩意都忘干净了

• 作者：笠原JunE 发布时间：2021-05-08 14:21:52

  2016.4.16 我建议当你想讨论转基因之前，先把这本书啃完

• 作者：Lloyd 发布时间：2020-07-30 11:27:05

  According to Freud, the ego remains in a constant state of tension trying to balance the demands of both the id and the superego.

• 作者：ChiChi 发布时间：2023-02-21 12:09:46

  读起来有稚嫩的地方，却又很成熟的感觉，让我了解了国外的课程是如何学习的，国内的教育真的是差很远啊

• 如果遇到读不懂的地方可以尝试看原文

  作者：会跳舞的青蛙 发布时间：2023-02-25 21:06:06

  原书第 60 页，第 6 段，原文如下

  Therefore, almost all of the molecules that cells acquire, either through food intake or through biosynthesis, are somewhat insoluble in water. These molecules, by their thermal movements, randomly collide with other molecules until they find complementary molecular surfaces on which to attach and thereby release water molecules for water–water interactions.

  谷歌翻译如下，

  另一方面，葡萄糖和丙酮酸等极性分子含有大量可形成极佳氢键的基团（例如 =O 或 OH），可溶于水（即它们是亲水性而非疏水性）。 尽管将这些基团插入水晶格会破坏水-水氢键，但同时会导致极性有机分子与水之间形成氢键。 然而，这些替代排列通常不像水-水排列那样在能量上令人满意，因此即使是最具极性的分子通常也只有有限的溶解度（见方框 3-1）。

  本译著为第 62 页，第 6 段，内容如下

  另一方面，那些含有大量能够形成氢键的基团(如 O 或 OH)的极性分子(如葡萄糖和丙酮酸)能够溶解于水[即它们是亲水的(hydrophilic)，而不是疏水的(h ydrophobic)]。当这类基团对水分子晶格的插入打断水-水氢键时，立即形成 了极性有机分子和水分子间氢键。然而在能量上，这种变化的排列一般不如水分子之间的排列稳定，因此即使是极性最大的分子一般也有一定的溶解度(框3-1)。

  所以最后应该是“也只有”或者“也仅有”，不然很难理解整段话。

• 沃森编的书，行

  作者：范范 发布时间：2017-05-07 10:45:13

  书的内容很好

  目前就我所读的分子生物学书里No.1

  有些内容在目前已出版分子生物学书籍中就某些机制的解释，不一致。或许存在争论吧。

  本书的缺点：一是非彩色的，二是贵。

  砖头书是肯定的，但都是精华。值得收藏。

  看的时候，最好做个笔记，方便自己知道了什么，哪里不理解。全书的逻辑性缜密，需要有耐心。